Bow-tie architecture of gene regulatory networks in species of varying complexity
Gourab Ghosh Roy, Shan He, Nicholas Geard, Karin Verspoor
JOURNAL OF THE ROYAL SOCIETY INTERFACE | ROYAL SOC | Published : 2021
The gene regulatory network (GRN) architecture plays a key role in explaining the biological differences between species. We aim to understand species differences in terms of some universally present dynamical properties of their gene regulatory systems. A network architectural feature associated with controlling system-level dynamical properties is the bow-tie, identified by a strongly connected subnetwork, the core layer, between two sets of nodes, the in and the out layers. Though a bow-tie architecture has been observed in many networks, its existence has not been extensively investigated in GRNs of species of widely varying biological complexity. We analyse publicly available GRNs of se..View full abstract
G.G.R. is supported by a Priestley Scholarship for joint study at the University of Birmingham and the University of Melbourne.