Taxonomic signatures of cause-specific mortality risk in human gut microbiome.
Aaro Salosensaari, Ville Laitinen, Aki S Havulinna, Guillaume Meric, Susan Cheng, Markus Perola, Liisa Valsta, Georg Alfthan, Michael Inouye, Jeramie D Watrous, Tao Long, Rodolfo A Salido, Karenina Sanders, Caitriona Brennan, Gregory C Humphrey, Jon G Sanders, Mohit Jain, Pekka Jousilahti, Veikko Salomaa, Rob Knight Show all
Nat Commun | Published : 2021
The collection of fecal material and developments in sequencing technologies have enabled standardised and non-invasive gut microbiome profiling. Microbiome composition from several large cohorts have been cross-sectionally linked to various lifestyle factors and diseases. In spite of these advances, prospective associations between microbiome composition and health have remained uncharacterised due to the lack of sufficiently large and representative population cohorts with comprehensive follow-up data. Here, we analyse the long-term association between gut microbiome variation and mortality in a well-phenotyped and representative population cohort from Finland (n = 7211). We report robust ..View full abstract
Awarded by NIEHS NIH HHS
Awarded by NIDDK NIH HHS
Awarded by NHLBI NIH HHS