Journal article

The ratio of morning cortisol to CRP prospectively predicts first-onset depression in at-risk adolescents

ER Landau, MB Raniti, M Blake, JM Waloszek, L Blake, JG Simmons, O Schwartz, G Murray, J Trinder, NB Allen, ML Byrne



RATIONALE: Early-onset adolescent depression is related to poor prognosis and a range of psychiatric and medical comorbidities later in life, making the identification of a priori risk factors for depression highly important. Increasingly, dysregulated levels of immune and neuroendocrine markers, such as C-reactive protein (CRP) and cortisol, have been demonstrated as both precursors to and consequences of depression. However, longitudinal research with adolescent populations is limited and demonstrates mixed immuno-endocrine-depression links. OBJECTIVE: This study explored the putative bidirectional relationship between salivary measures of cortisol (Cort) and CRP, including the novel Cort:..

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Awarded by Australian National Health and Medical Research Council Grant

Awarded by U.S. National Institute of Mental Health

Funding Acknowledgements

The authors received funding from the Australian National Health and Medical Research Council Grant (APP1027076) ; they also thank the participants of the SENSE Study and the following individuals for their contributions to the project: Camille Dean, Stefanie Rosema, Viviana Lee, Jess Slonim, Michael Gate, Vanessa Rowell, Tamsen Franklin, Stefan Friedel, Lauren Ban, Lian Snoep, Natasa Stoilov, Anja Plagemann, Giovanni Andreoli, Alex Klein, Carra Simpson, Michael Wilson, Adam Pettitt, and the Pneumococcal Research Group at the Murdoch Children's Research Institute, Melbourne, Australia. Author MLB's research was supported by the U.S. National Institute of Mental Health under Award Number K01MH111951. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.