Association of markers of inflammation, the kynurenine pathway and B vitamins with age and mortality, and a signature of inflammaging.
Pierre-Antoine Dugué, Allison M Hodge, Arve Ulvik, Per M Ueland, Øivind Midttun, Sabina Rinaldi, Robert J Macinnis, Sherly X Li, Klaus Meyer, Anne-Sophie Navionis, Leon Flicker, Gianluca Severi, Dallas R English, Paolo Vineis, Grethe S Tell, Melissa C Southey, Roger L Milne, Graham G Giles
J Gerontol A Biol Sci Med Sci | Published : 2021
BACKGROUND: Inflammation is a key feature of aging. We aimed to i) investigate the association of 34 blood markers potentially involved in inflammatory processes with age and mortality, ii) develop a signature of 'inflammaging'. METHODS: Thirty-four blood markers relating to inflammation, B vitamin status and the kynurenine pathway were measured in 976 participants in the Melbourne Collaborative Cohort Study at baseline (median age=59 years) and follow-up (median age=70 years). Associations with age and mortality were assessed using linear and Cox regression, respectively. A parsimonious signature of inflammaging was developed and its association with mortality was compared with two marker s..View full abstract