Journal article

Opportunities for innovation: Building on the success of lipid nanoparticle vaccines

Jessica Huang, Daniel Yuen, Justine D Mintern, Angus PR Johnston

CURRENT OPINION IN COLLOID & INTERFACE SCIENCE | ELSEVIER SCIENCE LONDON | Published : 2021

Abstract

Lipid nanoparticle (LNP) formulations of messenger RNA (mRNA) have demonstrated high efficacy as vaccines against SARS-CoV-2. The success of these nanoformulations underscores the potential of LNPs as a delivery system for next-generation biological therapies. In this article, we highlight the key considerations necessary for engineering LNPs as a vaccine delivery system and explore areas for further optimisation. There remain opportunities to improve the protection of mRNA, optimise cytosolic delivery, target specific cells, minimise adverse side-effects and control the release of RNA from the particle. The modular nature of LNP formulations and the flexibility of mRNA as a payload provide ..

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Grants

Awarded by National Health and Medical Research Council


Awarded by Australian Research Council


Funding Acknowledgements

This research was supported by a National Health and Medical Research Council Project Grant (1129672-APRJ) and Career Development Fellowship (1141551-APRJ) as well as the Australian Research Council through the Discovery Project Scheme (DP200100475, DP210103174-APRJ) . APRJ was also supported through the Monash University Larkin's Fellowship Scheme.