Journal article

Sex hormones, vascular factors and cognition

C Szoeke, SJ Downie, AF Parker, S Phillips



After more than a century of research, we have failed to develop a pharmacological prevention or cure for dementia. There are strong indicators that sex hormones influence cognition. In this paper we discuss the role of these hormones at the intersection between vascular disease and dementia, in light of the mounting literature covering the shared risk factors, pathological features alongside the timeline of hormonal change with the evolution of vascular and neurodegenerative disease. Interactive risk factors and the role of inflammation over the duration of disease evolution are highlighted. Our summary tables assessing the impact of estrogen-based hormone therapy on cognition over the past..

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Awarded by National Health and Medical Research Council (NHMRC)

Awarded by Alzheimer's Association

Funding Acknowledgements

Funding for the Healthy Ageing Program (HAP) has been provided by the National Health and Medical Research Council (NHMRC Grants 547600, 1032350 & 1062133) , Ramaciotti Foundation, Australian Healthy Ageing Organisation, the Brain Foundation, the Alzheimer's Association (NIA320312) , Australasian Menopause Society, Bayer Healthcare, Shepherd Foundation, Scobie and Claire Mackinnon Foundation, Collier Trust Fund, J.O. & J.R. Wicking Trust, Mason Foundation, Alzheimer's Association of Australia, and Royal Austra-lian College of Physicians. Inaugural funding for the project was pro-vided by VicHealth and the NHMRC. The Principal Investigator of HAP (Cassandra Szoeke) is supported by the National Health and Medical Research Council.