Journal article

Frequency-Dependent Competition Between Strains Imparts Persistence to Perturbations in a Model of Plasmodium falciparum Malaria Transmission

Qixin He, Shai Pilosof, Kathryn E Tiedje, Karen P Day, Mercedes Pascual

FRONTIERS IN ECOLOGY AND EVOLUTION | FRONTIERS MEDIA SA | Published : 2021

Abstract

In high-transmission endemic regions, local populations of Plasmodium falciparum exhibit vast diversity of the var genes encoding its major surface antigen, with each parasite comprising multiple copies from this diverse gene pool. This strategy to evade the immune system through large combinatorial antigenic diversity is common to other hyperdiverse pathogens. It underlies a series of fundamental epidemiological characteristics, including large reservoirs of transmission from high prevalence of asymptomatics and long-lasting infections. Previous theory has shown that negative frequency-dependent selection (NFDS) mediated by the acquisition of specific immunity by hosts structures the divers..

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Grants

Awarded by Fogarty International Center at the National Institutes of Health (Program on the Ecology and Evolution of Infectious Diseases)


Awarded by National Institute of Allergy and Infectious Disease, National Institutes of Health


Funding Acknowledgements

This study was supported by grants from the Fogarty International Center at the National Institutes of Health (Program on the Ecology and Evolution of Infectious Diseases), Grant number: R01-TW009670 to KD and MP; and the National Institute of Allergy and Infectious Disease, National Institutes of Health (Program on the Ecology and Evolution of Infectious Diseases), Grant number: R01-AI149779 to KD and MP. Salary support for QH was provided by R01-TW009670. Salary support for KT was provided by R01-TW009670 and The University of Melbourne.