Erectile Dysfunction in Men on the Rise: Is There a Link with Endocrine Disrupting Chemicals?
Samuel M Cripps, Deidre M Mattiske, Andrew J Pask
SEXUAL DEVELOPMENT | KARGER | Published : 2021
Erectile dysfunction (ED) is one of the most prevalent chronic conditions affecting men. ED can arise from disruptions during development, affecting the patterning of erectile tissues in the penis and/or disruptions in adulthood that impact sexual stimuli, neural pathways, molecular changes, and endocrine signalling that are required to drive erection. Sexual stimulation activates the parasympathetic system which causes nerve terminals in the penis to release nitric oxide (NO). As a result, the penile blood vessels dilate, allowing the penis to engorge with blood. This expansion subsequently compresses the veins surrounding the erectile tissue, restricting venous outflow. As a result, the bl..View full abstract
Aspects of this paper were supported by a project grant from the National Health and Medical Research Council to A.J.P.