Journal article
Postprandial Glucose Control Using the Medtronic Advanced Hybrid Closed-Loop System: Faster-Acting Insulin Aspart vs. Insulin Aspart
Melissa H Lee, Sara Vogrin, Barbora Paldus, Dale Morrison, Dessi Zaharieva, Jean Lu, Hannah Jones, Sue A Wyatt, Emma Netzer, Catriona M Sims, Richard Macisaac, Benyamin Grosman, Anirban Roy, Natalie Kurtz, Alicia Jenkins, David N Oneal
DIABETES | AMER DIABETES ASSOC | Published : 2020
DOI: 10.2337/db20-234-OR
Abstract
Background: Faster-acting insulin aspart (FiAsp) may improve responsiveness of closed-loop (CL) systems and provide better postprandial glucose (PPG) management due to its more rapid onset and offset compared to insulin aspart (Asp). The Medtronic Advanced Hybrid Closed Loop (AHCL) System features auto-basal and auto-bolus functions. Aim: To compare PPG control using FiAsp vs. Asp delivered using AHCL. Methods: Twelve adults with T1D (median HbA1c 7.1% [IQR 6.8, 7.2]; 54mmol/mol [51, 55]) were assigned to FiAsp or Asp (unblinded) in random-order over two-stages (6-weeks duration each) using AHCL. Postprandial periods were defined using set time-blocks for breakf..
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