Journal article

NEAT1 regulates neuroglial cell mediating Aβ clearance via the epigenetic regulation of endocytosis-related genes expression.

Ziqiang Wang, Yiwan Zhao, Naihan Xu, Shikuan Zhang, Songmao Wang, Yunhao Mao, Yuanchang Zhu, Bing Li, Yuyang Jiang, Ying Tan, Weidong Xie, Burton B Yang, Yaou Zhang

Cell Mol Life Sci | Published : 2019

Abstract

The accumulation of intracellular β-amyloid peptide (Aβ) is important pathological characteristic of Alzheimer's disease (AD). However, the exact underlying molecular mechanism remains to be elucidated. Here, we reported that Nuclear Paraspeckle Assembly Transcript 1 (NEAT1), a long n on-coding RNA, exhibits repressed expression in the early stage of AD and its down-regulation declines neuroglial cell mediating Aβ clearance via inhibiting expression of endocytosis-related genes. We find that NEAT1 is associated with P300/CBP complex and its inhibition affects H3K27 acetylation (H3K27Ac) and H3K27 crotonylation (H3K27Cro) located nearby to the transcription start site of many genes, including..

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University of Melbourne Researchers