Journal article
A Novel Polyacrylamide Magnetic Nanoparticle Contrast Agent for Molecular Imaging using MRI
Bradford A Moffat, G Ramachandra Reddy, Patrick McConville, Daniel E Hall, Thomas L Chenevert, Raoul R Kopelman, Martin Philbert, Ralph Weissleder, Alnawaz Rehemtulla, Brian D Ross
Molecular Imaging | SAGE Publications | Published : 2003
Open access
Abstract
A novel Polyacrylamide superparamagnetic iron oxide nanoparticle platform is described which has been synthetically prepared such that multiple crystals of iron oxide are encapsulated within a single Polyacrylamide matrix ( Poly Acrylamide Magnetic [PAM] nanoparticles). This formulation provides for an extremely large T 2 and T 2 * relaxivity of between 620 and 1140 sec −1 mM −1 . Administration of PAM nanoparticles into rats bearing orthotopic 9L gliomas allowed quantitative pharmacokinetic analysis of the uptake ..
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