Conference Proceedings
THU0350 Time dependent association of active renal disease with irreversible organ damage accrual in systemic lupus erythematosus
E Morand, R Kandane-Rathnayake, W Louthrenoo, S-F Luo, Y-J Wu, A Lateef, V Golder, S Sockalingam, S Navarra, L Zamora, L Hamijoyo, Y Katsumata, M Harigai, M Chan, S O'Neill, F Goldblatt, CS Lau, A Hoi, M Nikpour
Annals of the Rheumatic Diseases | Elsevier BV | Published : 2018
Abstract
Background Lupus nephritis (LN) is a common feature of systemic lupus erythematosus (SLE). While LN is considered a contributor to irreversible organ damage in SLE, the magnitude of impact of active renal disease relative to other contributors to damage accrual is unknown. Objectives To determine the time-dependent association of active lupus nephritis (LN) with organ damage accrual in SLE. Methods This study was performed on patients from the Asia Pacific Lupus Collaboration (APLC) cohort. SLE Disease Activity Index-2000 (SLEDAI-2k) is collected per-visit and SLICC-ACR Damage Index (SDI) annually. Analysis was restricted to patients with ≥2 SDI scores. Active LN was defined if patients had ..
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