Journal article

Vitamin D Receptor (VDR) Polymorphisms in Chronic Lymphocytic Leukaemia (CLL) Patients.

Faith Kwa, Miroslav Kapuscinski, Merrole Cole-Sinclair

Blood | American Society of Hematology | Published : 2007

Abstract

Abstract Chronic Lymphocytic Leukaemia (CLL) is a lymphoproliferative disorder in which leukaemic B cells are arrested in the G0/G1 phase of the cell cycle, resulting in their prolonged lifespan. The clinical course of CLL is highly variable with survival ranging from a few months to decades. Thus, a good prognostic tool is needed to help predict the course of the disease. The pathogenesis of CLL is unknown but it has been associated with the “escape” of B cells from apoptosis, possibly due to overexpression of anti-apoptotic genes and downregulation of pro-apoptotic genes. The expression of these genes is influenced by alterations in chromatin structure through a change in DN..

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