Synthesis of N-Acetyllactosamine and N-Acetyllactosamine-Based Bioactives
M Karimi Alavijeh, AS Meyer, SL Gras, SE Kentish
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | AMER CHEMICAL SOC | Published : 2021
N-Acetyllactosamine (LacNAc) or more specifically β-d-galactopyranosyl-1,4-N-acetyl-d-glucosamine is a unique acyl-amino sugar and a key structural unit in human milk oligosaccharides, an antigen component of many glycoproteins, and an antiviral active component for the development of effective drugs against viruses. LacNAc is useful itself and as a basic building block for producing various bioactive oligosaccharides, notably because this synthesis may be used to add value to dairy lactose. Despite a significant amount of information in the literature on the benefits, structures, and types of different LacNAc-derived oligosaccharides, knowledge about their effective synthesis for large-scal..View full abstract
M. Karimi Alavijeh acknowledges The University of Melbourne for a Melbourne Research Scholarship.