Journal article

Treatment of Swine Closed Head Injury with Perfluorocarbon NVX-428.

Francoise Arnaud, Ashraful Haque, Maj Erin Morris, Paula Moon-Massat, Charles Auker, Saha Biswajit, Brittany Hazzard, Lam Thuy Vi Tran Ho, Richard McCarron, Anke Scultetus

Med Sci (Basel) | MDPI AG | Published : 2020

Abstract

Pre-hospital treatment of traumatic brain injury (TBI) with co-existing polytrauma is complicated by requirements for intravenous fluid volume vs. hypotensive resuscitation. A low volume, small particle-size-oxygen-carrier perfluorocarbon emulsion NVX-428 (dodecafluoropentane emulsion; 2% w/v) could improve brain tissue with minimal additional fluid volume. This study examined whether the oxygen-carrier NVX-428 shows safety and efficacy for pre-hospital treatment of TBI. Anesthetized swine underwent fluid percussion injury TBI and received 1 mL/kg IV NVX-428 (TBI-NVX) at 15 min (T15) or normal saline (no-treatment) (TBI-NON). Similarly, uninjured swine received NVX-428 (SHAM-NVX) or normal s..

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University of Melbourne Researchers