Hypobaria during long-range flight resulted in significantly increased histopathological evidence of lung and brain damage in a swine model.
Anke H Scultetus, Michelle A Jefferson, Ashraful Haque, Lam Thuy Vi Tran Ho, Brittany Hazzard, Biswajit K Saha, Steve J Chun, Charles R Auker, Paula F Moon-Massat, Richard M McCarron, Debra L Malone
J Trauma Acute Care Surg | Published : 2019
BACKGROUND: Aeromedical evacuation to definitive care is standard in current military conflicts. However, there is minimal knowledge on the effects of hypobaria (HYPO) on either the flight crew or patients. The effects of HYPO were investigated using healthy swine. METHODS: Anesthetized Yorkshire swine underwent a simulated 4 h "transport" to an altitude of 2,441 m (8,000 feet.; HYPO, N = 6) or at normobaric conditions (NORMO, N = 6). Physiologic and biochemical data were collected. Organ damage was assessed for hemorrhage, inflammation, edema, necrosis, and for lungs only, microatelectasis. RESULTS: All parameters were similar prior to and after "transport" with no significant effects of HY..View full abstract