Journal article
Hypobaria during long-range flight resulted in significantly increased histopathological evidence of lung and brain damage in a swine model
Anke H Scultetus, Michelle A Jefferson, Ashraful Haque, Thuy Vi Tran Ho Lam, Brittany Hazzard, Biswajit K Saha, Steve J Chun, Charles R Auker, Paula F Moon-Massat, Richard M McCarron, Debra L Malone
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY | LIPPINCOTT WILLIAMS & WILKINS | Published : 2019
Abstract
BACKGROUND: Aeromedical evacuation to definitive care is standard in current military conflicts. However, there is minimal knowledge on the effects of hypobaria (HYPO) on either the flight crew or patients. The effects of HYPO were investigated using healthy swine. METHODS: Anesthetized Yorkshire swine underwent a simulated 4 h "transport" to an altitude of 2,441 m (8,000 feet.; HYPO, N = 6) or at normobaric conditions (NORMO, N = 6). Physiologic and biochemical data were collected. Organ damage was assessed for hemorrhage, inflammation, edema, necrosis, and for lungs only, microatelectasis. RESULTS: All parameters were similar prior to and after "transport" with no significant effects of HY..
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Awarded by CDMRP award
Funding Acknowledgements
For all authors, no conflicts are declared. This work was funded by CDMRP award W81XWH-13-2-0022. This article was presented (D. Malone) as an oral quick shot at the 31st.