The Effect of Different Round Window Sealants on Cochlear Mechanics Over Time
Timothy Mclean, Philip Clamp, Luke Campbell, Amy Hampson, Scott Chambers, Aaron Collins, Christofer Bester, Stephen O'Leary
OTOLOGY & NEUROTOLOGY | LIPPINCOTT WILLIAMS & WILKINS | Published : 2021
BACKGROUND: This project investigated the effects of round window membrane (RWM) sealants after surgical incision, with a focus on audiological thresholds, ossicular mechanics, and the impact upon cochlear function and pathology. METHODS: Twenty-eight guinea pigs were randomly allocated to one of three sealant groups (muscle, n = 7; fascia, n = 7, Tisseel, n = 8) or an unsealed control group (n = 6). Preoperative hearing was measured using auditory brainstem responses (ABRs). The ossicular chain and RWM were exposed surgically, and Laser Doppler Vibrometry (LDV) measurements were obtained from the long process of the incus. The RWM was incised then sealed (or left unsealed) according to grou..View full abstract
Awarded by National Health and Medical Research Council (Australia)
This work was funded by the National Health and Medical Research Council (Australia), GNT1007948.