Journal article

Protocol for a randomised controlled trial comparing two CPAP levels to prevent extubation failure in extremely preterm infants

Anna Madeline Kidman, Brett James Manley, Rosemarie Anne Boland, Atul Malhotra, Susan M Donath, Peter G Davis, Risha Bhatia



INTRODUCTION: Respiratory distress syndrome is a complication of prematurity and extremely preterm infants born before 28 weeks' gestation often require endotracheal intubation and mechanical ventilation. In this high-risk population, mechanical ventilation is associated with lung injury and contributes to bronchopulmonary dysplasia. Therefore, clinicians attempt to extubate infants as quickly and use non-invasive respiratory support such as nasal continuous positive airway pressure (CPAP) to facilitate the transition. However, approximately 60% of extremely preterm infants experience 'extubation failure' and require reintubation. While CPAP pressures of 5-8 cm H2O are commonly used, the opt..

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Awarded by NHMRC, GNT

Funding Acknowledgements

This research received no specific grant from any funding agency in the public, commercial or not--for--profit sectors. However, AMK would like to thank the centre for research excellence in Newborn Medicine for their support NHMRC, GNT 1153176.