Journal article

Protocol for a randomised controlled trial comparing two CPAP levels to prevent extubation failure in extremely preterm infants

Anna Madeline Kidman, Brett James Manley, Rosemarie Anne Boland, Atul Malhotra, Susan M Donath, Peter G Davis, Risha Bhatia

BMJ OPEN | BMJ PUBLISHING GROUP | Published : 2021

Abstract

INTRODUCTION: Respiratory distress syndrome is a complication of prematurity and extremely preterm infants born before 28 weeks' gestation often require endotracheal intubation and mechanical ventilation. In this high-risk population, mechanical ventilation is associated with lung injury and contributes to bronchopulmonary dysplasia. Therefore, clinicians attempt to extubate infants as quickly and use non-invasive respiratory support such as nasal continuous positive airway pressure (CPAP) to facilitate the transition. However, approximately 60% of extremely preterm infants experience 'extubation failure' and require reintubation. While CPAP pressures of 5-8 cm H2O are commonly used, the opt..

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