Journal article

3,4-Difluorobenzocurcumin Inhibits Vegfc-Vegfr3-Erk Signalling to Block Developmental Lymphangiogenesis in Zebrafish

Kazuhide S Okuda, Mei Fong Ng, Nur Faizah Ruslan, Neil I Bower, Dedrick Soon Seng Song, Huijun Chen, Sungmin Baek, Philip S Crosier, Katarzyna Koltowska, Jonathan W Astin, Pei Jean Tan, Benjamin M Hogan, Vyomesh Patel

Pharmaceuticals | MDPI AG | Published : 2021

Abstract

Lymphangiogenesis, the formation of new lymphatic vessels from pre-existing vasculature, plays critical roles in disease, including in cancer metastasis and chronic inflammation. Preclinical and recent clinical studies have now demonstrated therapeutic utility for several anti-lymphangiogenic agents, but optimal agents and efficacy in different settings remain to be determined. We tested the anti-lymphangiogenic property of 3,4-Difluorobenzocurcumin (CDF), which has previously been implicated as an anti-cancer agent, using zebrafish embryos and cultured vascular endothelial cells. We used transgenic zebrafish labelling the lymphatic system and found that CDF potently inhibits lymphangiogenes..

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Grants

Awarded by National Heart Foundation/NHMRC


Funding Acknowledgements

This work was supported in part by the Terry Fox Run Kuala Lumpur grant (KO), Internal grant by the Cancer Research Malaysia (VP), and the National Heart Foundation/NHMRC Career Development Fellowship (BH, 1083811).