Journal article

C/EBP beta/AEP Signaling Regulates the Oxidative Stress in Malignant Cancers, Stimulating the Metastasis

Kecheng Lei, Seong Su Kang, Eun Hee Ahn, Chun Chen, Jianming Liao, Xia Liu, Hua Li, Laura E Edgington-Mitchell, Lingjing Jin, Keqiang Ye

MOLECULAR CANCER THERAPEUTICS | AMER ASSOC CANCER RESEARCH | Published : 2021

Abstract

Solid tumors start as a local disease, but some are capable of metastasizing to the lymph nodes and distant organs. The hypoxic microenvironment, which is critical during cancer development, plays a key role in regulating cancer progression and metastasis. However, the molecular mechanisms mediating the disseminated cancer cell metastasis remain incompletely understood. Here, we show that C/EBPβ/AEP signaling that is upregulated in breast cancers mediates oxidative stress and lung metastasis, and inactivation of asparagine endopeptidase (AEP, also known as legumain) robustly regulates breast cancer reactive oxygen species (ROS) and metastasis. AEP, a protease activated in acidic conditions, ..

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Grants

Awarded by NCI, NIH NIH grant


Awarded by China Postdoctoral Science Foundation


Awarded by Program of Shanghai Academic Research Leader


Funding Acknowledgements

This work is funded with Federal funds from the NCI, NIH NIH grant RO1 CA186918 (to K. Ye). K. Lei was supported by a grant from the China Postdoctoral Science Foundation (2018M632168). This work is also sponsored by the Program of Shanghai Academic Research Leader 20XD1403400 (to L. Jin).