Journal article

Melatonin augments the neuroprotective effects of hypothermia in lambs following perinatal asphyxia

James DS Aridas, Tamara Yawno, Amy E Sutherland, Ilias Nitsos, Flora Y Wong, Rod W Hunt, Michael Ditchfield, Michael C Fahey, Atul Malhotra, Euan M Wallace, Alistair J Gunn, Graham Jenkin, Suzanne L Miller

JOURNAL OF PINEAL RESEARCH | WILEY | Published : 2021

Abstract

Therapeutic hypothermia (TH) is standard care in high-resource birth settings for infants with neonatal encephalopathy. TH is partially effective and adjuvant therapies are needed. Here, we examined whether the antioxidant melatonin (MLT) provides additive benefit with TH, compared to TH alone or MLT alone, to improve recovery from acute encephalopathy in newborn lambs. Immediately before cesarean section delivery, we induced asphyxia in fetal sheep via umbilical cord occlusion until mean arterial blood pressure fell from 55 ± 3 mm Hg in sham controls to 18-20 mm Hg (10.1 ± 1.5 minutes). Lambs were delivered and randomized to control, control + MLT (60 mg iv, from 30 minutes to 24 hours), as..

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