Journal article

The AT2 gene may have a gender-specific effect on kidney function and pulse pressure in type I diabetic patients

K Pettersson-Fernholm, S Frojdo, J Fagerudd, MC Thomas, C Forsblom, M Wessman, P-H Groop

KIDNEY INTERNATIONAL | ELSEVIER SCIENCE INC | Published : 2006

Abstract

Diabetic nephropathy shows a higher incidence in male subjects, which may in part be owing to genetic factors. The angiotensin II type 2 receptor (AT2), present in the renal glomerulus, may oppose the deleterious effects of the type I receptor (AT1) through vasodilatation and growth inhibition. We determined whether the functional intronic G1675A or A1818T polymorphism of the X-chromosomal AT2 gene is associated with blood pressure levels or with kidney function. We genotyped 996 (538 female/458 male subjects) Finnish patients with type I diabetes from the FinnDiane-study in a cross-sectional study. DNA samples were amplified using standard polymerase chain reaction protocol and the genotype..

View full abstract

University of Melbourne Researchers