Prospects of Using High-Throughput Proteomics to Underpin the Discovery of Animal Host-Nematode Interactions
Tao Wang, Robin B Gasser
PATHOGENS | MDPI | Published : 2021
Parasitic nematodes impose a significant public health burden, and cause major economic losses to agriculture worldwide. Due to the widespread of anthelmintic resistance and lack of effective vaccines for most nematode species, there is an urgent need to discover novel therapeutic and vaccine targets, informed through an understanding of host-parasite interactions. Proteomics, underpinned by genomics, enables the global characterisation proteins expressed in a particular cell type, tissue and organism, and provides a key to insights at the host-parasite interface using advanced high-throughput mass spectrometry-based proteomic technologies. Here, we (i) review current mass-spectrometry-based..View full abstract
RBG's research program is supported by the Australian Research Council (ARC), the National Health and Medical Research Council (NHMRC) of Australia, and industry partners including Yourgene Health (Singapore) Pte Ltd.