Severe thrombocytopenia is sufficient for fetal and neonatal intracerebral hemorrhage to occur
Alison Farley, Sarah Lloyd, Merle Dayton, Christine Biben, Olivia Stonehouse, Samir Taoudi
BLOOD | AMER SOC HEMATOLOGY | Published : 2021
Intracerebral hemorrhage (ICH) has a devastating impact on the neonatal population. Whether thrombocytopenia is sufficient to cause ICH in neonates is still being debated. In this study, we comprehensively investigated the consequences of severe thrombocytopenia on the integrity of the cerebral vasculature by using 2 orthogonal approaches: by studying embryogenesis in the Nfe2-/- mouse line and by using biologics (anti-GP1Bα antibodies) to induce severe thrombocytopenia at defined times during development. By using a mouse model, we acquired data demonstrating that platelets are required throughout fetal development and into neonatal life for maintaining the integrity of the cerebral vascula..View full abstract
Awarded by National Health and Medical Research Council (NHMRC)
Awarded by Cerebral Palsy Alliance
Awarded by NHMRC
The authors thank Marnie Blewitt and Antoine Terreaux for critical comments on the manuscript, and Mirella Dottori and Samantha Chandler (consumer advocate) for insightful advice. This work was supported by the Australian Research Council Stem Cells Australia Program, and by grants from the National Health and Medical Research Council (NHMRC) (1128993 and 1129012), Cerebral Palsy Alliance (PG12418), Independent Research Institutes Infrastructure Support Scheme, NHMRC (361646), the Australian Cancer Research Fund, and Victorian State Government Operational Infrastructure Support. S.T. was supported by a fellowship from the Lorenzo and Pamela Galli Charitable Trust.