Journal article

Long-Term Blood Pressure Variability and Risk of Cognitive Decline and Dementia Among Older Adults

Michael E Ernst, Joanne Ryan, Enayet K Chowdhury, Karen L Margolis, Lawrence J Beilin, Christopher M Reid, Mark R Nelson, Robyn L Woods, Raj C Shah, Suzanne G Orchard, Rory Wolfe, Elsdon Storey, Andrew M Tonkin, Amy Brodtmann, John J McNeil, Anne M Murray

JOURNAL OF THE AMERICAN HEART ASSOCIATION | WILEY | Published : 2021

Abstract

Background Blood pressure variability (BPV) in midlife increases risk of late-life dementia, but the impact of BPV on the cognition of adults who have already reached older ages free of major cognitive deficits is unknown. We examined the risk of incident dementia and cognitive decline associated with long-term, visit-to-visit BPV in a post hoc analysis of the ASPREE (Aspirin in Reducing Events in the Elderly) trial. Methods and Results ASPREE participants (N=19 114) were free of dementia and significant cognitive impairment at enrollment. Measurement of BP and administration of a standardized cognitive battery evaluating global cognition, delayed episodic memory, verbal fluency, and process..

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University of Melbourne Researchers