Journal article
Long-term blood pressure variability and risk of cognitive decline and dementia among older adults
ME Ernst, J Ryan, EK Chowdhury, KL Margolis, LJ Beilin, CM Reid, MR Nelson, RL Woods, RC Shah, SG Orchard, R Wolfe, E Storey, AM Tonkin, A Brodtmann, JJ McNeil, AM Murray
Journal of the American Heart Association | WILEY | Published : 2021
Abstract
BACKGROUND: Blood pressure variability (BPV) in midlife increases risk of late-life dementia, but the impact of BPV on the cognition of adults who have already reached older ages free of major cognitive deficits is unknown. We examined the risk of incident dementia and cognitive decline associated with long-term, visit-to-visit BPV in a post hoc analysis of the ASPREE (Aspirin in Reducing Events in the Elderly) trial. METHODS AND RESULTS: ASPREE participants (N=19 114) were free of dementia and significant cognitive impairment at enrollment. Measurement of BP and administration of a standardized cognitive battery evaluating global cognition, delayed episodic memory, verbal fluency, and proce..
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Awarded by Monash University
Funding Acknowledgements
The ASPREE trial was supported by grants (U01AG029824 and U19AG062682) from the National Institute on Aging and the National Cancer Institute at the National Institutes of Health, by grants (334047 and 1127060) from the National Health and Medical Research Council of Australia, and by Monash University and the Victorian Cancer Agency.