Journal article

Characteristics of Early-Onset vs Late-Onset Colorectal Cancer A Review

Alexandra M Zaborowski, Ahmed Abdile, Michel Adamina, Felix Aigner, Laura d'Allens, Caterina Allmer, Andrea Alvarez, Rocio Anula, Mihailo Andric, Sam Atallah, Simon Bach, Miklosh Bala, Marie Barussaud, Augustinas Bausys, Brendan Bebington, Andrew Beggs, Felipe Bellolio, Melissa-Rose Bennett, Anton Berdinskikh, Vicki Bevan Show all

JAMA SURGERY | AMER MEDICAL ASSOC | Published : 2021

Abstract

Importance: The incidence of early-onset colorectal cancer (younger than 50 years) is rising globally, the reasons for which are unclear. It appears to represent a unique disease process with different clinical, pathological, and molecular characteristics compared with late-onset colorectal cancer. Data on oncological outcomes are limited, and sensitivity to conventional neoadjuvant and adjuvant therapy regimens appear to be unknown. The purpose of this review is to summarize the available literature on early-onset colorectal cancer. Observations: Within the next decade, it is estimated that 1 in 10 colon cancers and 1 in 4 rectal cancers will be diagnosed in adults younger than 50 years. Po..

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University of Melbourne Researchers