Journal article

Targeting the genetic landscape of oral potentially malignant disorders has the potential as a preventative strategy in oral cancer.

SS Prime, N Cirillo, SC Cheong, MS Prime, EK Parkinson

Cancer Lett | Published : 2021

Abstract

This study reviews the molecular landscape of oral potentially malignant disorders (OPMD). We examine the impact of tumour heterogeneity, the spectrum of driver mutations (TP53, CDKN2A, TERT, NOTCH1, AJUBA, PIK3CA, CASP8) and gene transcription on tumour progression. We comment on how some of these mutations impact cellular senescence, field cancerization and cancer stem cells. We propose that OPMD can be monitored more closely and more dynamically through the use of liquid biopsies using an appropriate biomarker of transformation. We describe new gene interactions through the use of a systems biology approach and we highlight some of the first studies to identify functional genes using CRIS..

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University of Melbourne Researchers