Journal article

Abstract WP71: Gradient of Tissue Injury on Diffusion Tensor Imaging After Stroke: Rethinking the Infarct vs Non-infarcted Dichotomy

Felix Ng, Vijay Venkatraman, Mark Parsons, Andrew Bivard, Gagan Sharma, Leonid Churilov, Patricia Desmond, Stephen Davis, Nawaf Yassi, Bruce Campbell

Stroke | Ovid Technologies (Wolters Kluwer Health) | Published : 2020


Objective: To evaluate the degree of variability in microstructural injury within and adjacent to regions identified as infarcted tissue using Diffusion Tensor Imaging (DTI). Methods: Perfusion CT was performed in 18 patients within 12 hours of ischemic stroke onset followed by Fluid-attenuated Inversion recovery (FLAIR) and DTI one month after stroke. Four regions of interest (ROIs) corresponding to the severity of hypoperfusion on CT perfusion within and beyond the radiological infarct lesion defined on FLAIR were segmented. Fractional anisotropy (FA) and mean diffusivity (MD) were quantified for each ROI and compared to a mirror ho..

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