Journal article

Time-course analysis of metabolomic and microbial responses in anaerobic digesters exposed to ammonia

Olivier Chapleur, Simon Poirier, Angeline Guenne, Kim-Anh Le Cao



Omics longitudinal studies are effective experimental designs to inform on the stability and dynamics of microbial communities in response to perturbations, but time-course analytical frameworks are required to fully exploit the temporal information acquired in this context. In this study we investigate the influence of ammonia on the stability of anaerobic digestion (AD) microbiome with a new statistical framework. Ammonia can severely reduce AD performance. Understanding how it affects microbial communities development and the degradation progress is a key operational issue to propose more stable processes. Thirty batch digesters were set-up with different levels of ammonia. Microbial comm..

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University of Melbourne Researchers


Awarded by National Health and Medical Research Council (NHMRC) Career Development fellowship

Awarded by National Research Agency

Funding Acknowledgements

Kim-Anh Le Cao and Olivier Chapleur scientific travels were supported in part by the France-Australia Science Innovation Collaboration (FASIC) Program Early Career Fellowships from Campus France and the Australian Academy of Science. KALC was supported in part by the National Health and Medical Research Council (NHMRC) Career Development fellowship (GNT1159458). This work was conducted as part of the STABILICS project supported by the National Research Agency (ANR-19-CE43-0003). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.