Journal article
Antibody responses to collagen peptides and streptococcal collagen-like 1 proteins in acute rheumatic fever patients
DH Pilapitiya, PWR Harris, P Hanson-Manful, R McGregor, R Kowalczyk, JM Raynes, LH Carlton, RCJ Dobson, MG Baker, M Brimble, S Lukomski, NJ Moreland
Pathogens and Disease | Published : 2021
Abstract
Acute rheumatic fever (ARF) is a serious post-infectious immune sequelae of Group A streptococcus (GAS). Pathogenesis remains poorly understood, including the events associated with collagen autoantibody generation. GAS express streptococcal collagen-like proteins (Scl) that contain a collagenous domain resembling human collagen. Here, the relationship between antibody reactivity to GAS Scl proteins and human collagen in ARF was investigated. Serum IgG specific for a representative Scl protein (Scl1.1) together with collagen-I and collagen-IV mimetic peptides were quantified in ARF patients (n = 36) and healthy matched controls (n = 36). Reactivity to Scl1.1 was significantly elevated in ARF..
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Awarded by National Institute of Allergy and Infectious Diseases
Funding Acknowledgements
This work was supported by funding from the Maurice Wilkins Centre forMolecular Biodiscovery. NJMwas funded by a National Heart Foundation Senior Research Fellowship for part of the study period. The Rheumatic Fever Risk Factors study, from which samples were obtained, was funded by the Heath Research Council of New Zealand (HRC) Rheumatic Fever Research Partnership (Ministry of Health, Te Puni Kokiri, Cure Kids, Heart Foundation and HRC). Thisworkwas also partly supported by the National Institutes of Health Grants AI50666 and AI083683 (to SL). We thank staff in paediatric departments across the North Island of New Zealand for kind support and assistance. All members of the Rheumatic Fever Risk Factors Study (in addition to the authors on this manuscript) are gratefully acknowledged.