Idebenone: When an antioxidant is not an antioxidant
Nuri Gueven, Pranathi Ravishankar, Rajaraman Eri, Emma Rybalka
REDOX BIOLOGY | ELSEVIER | Published : 2021
Idebenone is a well described drug that was initially developed against dementia. The current literature widely portrays this molecule as a potent antioxidant and CoQ10 analogue. While numerous papers seem to support this view, a closer look indicates that the pharmacokinetics of idebenone do not support these claims. A major discrepancy between achievable tissue levels, especially in target tissues such as the brain, and doses required to show the proposed effects, significantly questions our current understanding. This review explains how this has happened and highlights the discrepancies in the current literature. More importantly, based on some recent discoveries, a new framework is pres..View full abstract
We would like to acknowledge the support of the University of Tasmania and Victoria University for the preparation of this manuscript.