Journal article

Putative Causal Variants Are Enriched in Annotated Functional Regions From Six Bovine Tissues

Claire P Prowse-Wilkins, Jianghui Wang, Ruidong Xiang, Josie B Garner, Michael E Goddard, Amanda J Chamberlain

FRONTIERS IN GENETICS | FRONTIERS MEDIA SA | Published : 2021

Abstract

Genetic variants which affect complex traits (causal variants) are thought to be found in functional regions of the genome. Identifying causal variants would be useful for predicting complex trait phenotypes in dairy cows, however, functional regions are poorly annotated in the bovine genome. Functional regions can be identified on a genome-wide scale by assaying for post-translational modifications to histone proteins (histone modifications) and proteins interacting with the genome (e.g., transcription factors) using a method called Chromatin immunoprecipitation followed by sequencing (ChIP-seq). In this study ChIP-seq was performed to find functional regions in the bovine genome by assayin..

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Grants

Awarded by Australian Research Council


Funding Acknowledgements

This project was funded by the DairyBio (a joint venture project between Agriculture Victoria and Dairy Australia). Australian Research Council's Discovery Projects (DP160101056) supported RX and MG. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.