Corneal immune cell morphometry as an indicator of local and systemic pathology: A review
Holly R Chinnery, Xin Yuan Zhang, Ching Yi Wu, Laura E Downie
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY | WILEY | Published : 2021
The corneal epithelium contains a population of resident immune cells commonly referred to as dendritic cells (DCs), or Langerhans cells. A unique advantage of the transparent cornea being situated at the surface of the eye is that these cells can be readily visualised using in vivo confocal microscopy. Over the past decade, interest in the involvement of corneal DCs in a range of ocular and systemic diseases has surged. For most studies, the number of corneal DCs has been the main outcome of interest. However, more recently attention has shifted towards understanding how DC morphology may provide insights into the inflammatory status of the cornea, and in some cases, the health of the perip..View full abstract
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Awarded by National Health and Medical Research Council
National Health and Medical Research Council Project Grant (HRC; APP1126540).