Journal article

Brain stimulation and brain lesions converge on common causal circuits in neuropsychiatric disease

Shan H Siddiqi, Frederic LWVJ Schaper, Andreas Horn, Joey Hsu, Jaya L Padmanabhan, Amy Brodtmann, Robin FH Cash, Maurizio Corbetta, Ki Sueng Choi, Darin D Dougherty, Natalia Egorova, Paul B Fitzgerald, Mark S George, Sophia A Gozzi, Frederike Irmen, Andrea A Kuhn, Kevin A Johnson, Andrew M Naidech, Alvaro Pascual-Leone, Thanh G Phan Show all



Damage to specific brain circuits can cause specific neuropsychiatric symptoms. Therapeutic stimulation to these same circuits may modulate these symptoms. To determine whether these circuits converge, we studied depression severity after brain lesions (n = 461, five datasets), transcranial magnetic stimulation (n = 151, four datasets) and deep brain stimulation (n = 101, five datasets). Lesions and stimulation sites most associated with depression severity were connected to a similar brain circuit across all 14 datasets (P < 0.001). Circuits derived from lesions, deep brain stimulation and transcranial magnetic stimulation were similar (P < 0.0005), as were circuits derived from patients wi..

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Awarded by National Institute of Mental Health

Funding Acknowledgements

The authors thank all research participants, funding bodies, allied health staff and other research staff that made this work possible. The present work was supported by the Sidney R. Baer Foundation (S.H.S., J.L.P., M.D.F.), the Brain & Behavior Research Foundation (SHS) and the National Institute of Mental Health (grant no. K23MH121657 to S.H.S.; grant nos. R01MH113929 and R01MH115949 to M.D.F.). The funders were not directly involved in the conceptualization, design, data collection, analysis, decision to publish or preparation of the manuscript.