Journal article

Recalcitrant lichen planopilaris and frontal fibrosing alopecia responding to tildrakizumab

Lara Trindade de Carvalho, Nekma Meah, Dmitri Wall, Rodney Sinclair

DERMATOLOGIC THERAPY | WILEY | Published : 2020

Abstract

Lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA) are lymphocytic, cicatricial alopecias. Clinically, LPP presents with multifocal patchy alopecia, while FFA, considered a variant of LPP, results in hairline recession. Frontal recession in FFA may progress as far as the mid-scalp and infrequently beyond. Treatment to arrest the inflammatory process can be challenging and response variable. We report a case of recalcitrant lichen planopilaris and frontal fibrosing alopecia demonstrating significant clinical improvement after four doses of the interleukin-23 monoclonal antibody tildrakizumab.