Journal article

Voltage-sensitive sodium channel (Vssc) mutations associated with pyrethroid insecticide resistance in Aedes aegypti (L.) from two districts of Jeddah, Kingdom of Saudi Arabia: baseline information for a Wolbachia release program

Nancy M Endersby-Harshman, AboElgasim Ali, Basim Alhumrani, Mohammed Abdullah Alkuriji, Mohammed B Al-Fageeh, Abdulaziz Al-Malik, Mohammed S Alsuabeyl, Samia Elfekih, Ary A Hoffmann

PARASITES & VECTORS | BMC | Published : 2021

Abstract

BACKGROUND: Dengue suppression often relies on control of the mosquito vector, Aedes aegypti, through applications of insecticides of which the pyrethroid group has played a dominant role. Insecticide resistance is prevalent in Ae. aegypti around the world, and the resulting reduction of insecticide efficacy is likely to exacerbate the impact of dengue. Dengue has been a public health problem in Saudi Arabia, particularly in Jeddah, since its discovery there in the 1990s, and insecticide use for vector control is widespread throughout the city. An alternative approach to insecticide use, based on blocking dengue transmission in mosquitoes by the endosymbiont Wolbachia, is being trialed in Je..

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Grants

Awarded by KACST-CSIRO co-investment collaborative research agreement


Funding Acknowledgements

The study was funded under the KACST-CSIRO co-investment collaborative research agreement [ETSC&KACST-CSIRO-2018-12-30-21] on "Management strategies of vector-borne disease in Saudi Arabia: feasibility of the Wolbachia-based approach as an alternative to chemical pesticides."