Towards spatio-temporally resolved developmental cardiac gene regulatory networks in zebrafish.
Jeannette C Hallab, Hieu T Nim, Julian Stolper, Gulrez Chahal, Lisa Waylen, Francesca Bolk, David A Elliott, Enzo Porrello, Mirana Ramialison
Brief Funct Genomics | Published : 2021
Heart formation in the zebrafish involves a rapid, complex series of morphogenetic events in three-dimensional space that spans cardiac lineage specification through to chamber formation and maturation. This process is tightly orchestrated by a cardiac gene regulatory network (GRN), which ensures the precise spatio-temporal deployment of genes critical for heart formation. Alterations of the timing or spatial localisation of gene expression can have a significant impact in cardiac ontogeny and may lead to heart malformations. Hence, a better understanding of the cellular and molecular basis of congenital heart disease relies on understanding the behaviour of cardiac GRNs with precise spatiot..View full abstract