Journal article
Towards spatio-temporally resolved developmental cardiac gene regulatory networks in zebrafish
JC Hallab, HT Nim, J Stolper, G Chahal, L Waylen, F Bolk, DA Elliott, E Porrello, M Ramialison
Briefings in Functional Genomics | OXFORD UNIV PRESS | Published : 2021
DOI: 10.1093/bfgp/elab030
Open access
Abstract
Heart formation in the zebrafish involves a rapid, complex series of morphogenetic events in three-dimensional space that spans cardiac lineage specification through to chamber formation and maturation. This process is tightly orchestrated by a cardiac gene regulatory network (GRN), which ensures the precise spatio-temporal deployment of genes critical for heart formation. Alterations of the timing or spatial localisation of gene expression can have a significant impact in cardiac ontogeny and may lead to heart malformations. Hence, a better understanding of the cellular and molecular basis of congenital heart disease relies on understanding the behaviour of cardiac GRNs with precise spatiot..
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Awarded by Royal Children's Hospital Foundation
Funding Acknowledgements
We thank the members of the Ramialison Laboratory for their support. This project is funded by the Australian Research Council Discovery Project DP190102771 to M.R. and GS is funded by a Rotary Global Grant, Rotary Foundation International [GG1637399]. Further support was received from the National Health and Medical Research Council of Australia (D.A.E., E.R.P.), Australian Research Council (E.R.P., M.R.), Heart Foundation of Australia (D.A.E.), The Stafford Fox Medical Research Foundation (D.A.E., E.R.P., M.R.) and the Royal Children's Hospital Foundation (D.A.E., E.R.P.). Murdoch Childrens Research Institute supported by Victorian Government's Operational Infrastructure Support Program and Australian Government National Health and Medical Research Council Independent Research Institute Infrastructure Support Scheme (NHMRC IRIISS). The Australian Regenerative Medicine Institute is supported by grants from the State Government of Victoria and the Australian Government.