Journal article

Abstract 171: Urea Cycle Intermediates and Nitric Oxide Synthase Metabolites Decrease Whilst Asymmetric Dimethylarginine Remained Unchanged Following Cardiac Surgery

John Garlick, Amy Wilson-O'Brien, Konstantinos A Kouremenos, Nicholas Williamson, Andrew Wilson

Arteriosclerosis, Thrombosis, and Vascular Biology | Ovid Technologies (Wolters Kluwer Health) | Published : 2016


Background: Within the endothelium, Nitric Oxide Synthase (NOS) activity through the conversion of Arginine to Citrulline and Nitric Oxide (NO) is largely seen as beneficial. NO is a powerful bioactive molecule which elicits an antithrombotic and antioxidant effect preventing platelet aggregation and atherosclerosis. In immune cells NOS however is largely thought to be beneficial as a microbicidal agent involved in inflammatory responses. Systemic inflammation is also a common outcome in patients undergoing cardiac surgery and those receiving Cardiopulmonary Bypass (CPB) due to contact with foreign surfaces and surgical trauma. Through the Urea Cycle, Citrulline is converted back..

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