Journal article

Porpoise: a new approach for accurate prediction of RNA pseudouridine sites.

Fuyi Li, Xudong Guo, Peipei Jin, Jinxiang Chen, Dongxu Xiang, Jiangning Song, Lachlan JM Coin

Brief Bioinform | Published : 2021

Abstract

Pseudouridine is a ubiquitous RNA modification type present in eukaryotes and prokaryotes, which plays a vital role in various biological processes. Almost all kinds of RNAs are subject to this modification. However, it remains a great challenge to identify pseudouridine sites via experimental approaches, requiring expensive and time-consuming experimental research. Therefore, computational approaches that can be used to perform accurate in silico identification of pseudouridine sites from the large amount of RNA sequence data are highly desirable and can aid in the functional elucidation of this critical modification. Here, we propose a new computational approach, termed Porpoise, to accura..

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University of Melbourne Researchers

Grants

Awarded by NHMRC career development fellowship


Awarded by NHMRC-EU project


Awarded by National Health and Medical Research Council of Australia


Awarded by Australian Research Council


Awarded by NIH HHS