Plasma Corona Protects Human Immune Cells from Structurally Nanoengineered Antimicrobial Peptide Polymers
Alessia CG Weiss, Steven J Shirbin, Hannah G Kelly, Quinn A Besford, Stephen J Kent, Greg G Qiao
ACS APPLIED MATERIALS & INTERFACES | AMER CHEMICAL SOC | Published : 2021
Safe and effective antimicrobials are needed to combat emerging antibiotic-resistant bacteria. Structurally nanoengineered antimicrobial peptide polymers (termed SNAPPs) interact with bacterial cell membranes to potently kill bacteria but may also interact at some level with human cell membranes. We studied the association of four different SNAPPs with six different white blood cells within fresh whole human blood by flow cytometry. In whole human blood, SNAPPs had detectable association with phagocytic cells and B cells, but not natural killer and T cells. However, without plasma proteins and therefore no protein corona on the SNAPPs, a greater marked association of SNAPPs with all white bl..View full abstract
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Awarded by Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology
Awarded by Australian Research Council (ARC)
This research was conducted and funded by the Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology (Project CE140100036). G.G.Q. acknowledges the Australian Research Council (ARC) for funding in the form of a Discovery Project (DP160101312).