Journal article

Relaxin-3 Innervation From the Nucleus Incertus to the Parahippocampal Cortex of the Rat

Cristina Garcia-Diaz, Isis Gil-Miravet, Hector Albert-Gasco, Aroa Manas-Ojeda, Francisco Ros-Bernal, Esther Castillo-Gomez, Andrew L Gundlach, Francisco E Olucha-Bordonau



Spatial learning and memory processes depend on anatomical and functional interactions between the hippocampus and the entorhinal cortex. A key neurophysiological component of these processes is hippocampal theta rhythm, which can be driven from subcortical areas including the pontine nucleus incertus (NI). The NI contains the largest population of neurons that produce and presumably release the neuropeptide, relaxin-3, which acts via the G i/o -protein-coupled receptor, relaxin-family peptide 3 receptor (RXFP3). NI activation induces general arousal including hippocampal theta, and inactivation induces impairment of spatial memory acquisition or retrieval. The primary aim of this study was ..

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University of Melbourne Researchers


Awarded by Fundacion Alicia Koplowitz, Spain

Awarded by Spanish Ministerio de Ciencia, Innovacion y Universidades

Awarded by Generalitat Valenciana

Awarded by National Health and Medical Research Council of Australia

Awarded by Universitat Jaume I

Funding Acknowledgements

This research was funded by the Fundacion Alicia Koplowitz, Spain, grant number 19I436 (FO-B, EC-G, and FR-B); the Spanish Ministerio de Ciencia, Innovacion y Universidades, grant number RTI2018095698-B-I00 (FO-B, EC-G, and FR-B); Generalitat Valenciana, grant number GV/2019/088 (EC-G), National Health and Medical Research Council of Australia, grant number 1067522 (AG), and Universitat Jaume I, grant numbers UJI-A2017-17 (FR-B) and UJI-B2019-54 (FO-B).