Journal article

Surveillance of molecular markers of Plasmodium falciparum artemisinin resistance (kelch13 mutations) in Papua New Guinea between 2016 and 2018

Dulcie Lautu-Gumal, Zahra Razook, Tamarah Koleala, Elma Nate, Samuel McEwen, Diana Timbi, Manuel W Hetzel, Evelyn Lavu, Nakapi Tefuarani, Leo Makita, James Kazura, Ivo Mueller, William Pomat, Moses Laman, Leanne J Robinson, Alyssa E Barry

INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE | ELSEVIER SCI LTD | Published : 2021

Abstract

Plasmodium falciparum resistance to artemisinin-based combination therapy (ACT) is a global threat to malaria control and elimination efforts. Mutations in the P. falciparum kelch13 gene (Pfk13) that are associated with delayed parasite clearance have emerged on the Thai-Cambodian border since 2008. There is growing evidence of widespread Pfk13 mutations throughout South-East Asia and they have independently emerged in other endemic regions. In Papua New Guinea (PNG), Pfk13 "C580Y" mutant parasites with reduced in vitro sensitivity to artemisinin have been isolated in Wewak, a port town in East Sepik Province. However, the extent of any local spread of these mutant parasites in other parts o..

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Grants

Awarded by Global Fund to Fight AIDS, Tuberculosis and Malaria


Awarded by WHO Tropical Disease Research Grant


Awarded by National Institutes of Health International Centre of Excellence in Malaria Research for the South West Pacific, USA


Awarded by Australian Centre for Research Excellence in Malaria Elimination (ACREME) - National Health and Medical Research Council (NHMRC) of Australia


Awarded by NHMRC


Funding Acknowledgements

Collection of samples for this work was supported by the Global Fund to Fight AIDS, Tuberculosis and Malaria (MIS 2016/17), a WHO Tropical Disease Research Grant (WCCPRD4426109 2016/639607), a PNGChina-Australia Trilateral Research Co-operation funded by Australian Department of Foreign Affairs and Trade (DFAT), a National Institutes of Health International Centre of Excellence in Malaria Research for the South West Pacific, USA (DMID Protocol #10-0035). The generation of molecular data was supported by STRIVE PNG, an Australian DFAT Centre for Health Security Stronger Health Systems Grant. DLG was supported by STRIVE PNG and the Australian Centre for Research Excellence in Malaria Elimination (ACREME) funded by the National Health and Medical Research Council (NHMRC) of Australia (APP1134989). LJR and IM were supported by NHMRC Research Fellowships (GNT1161627, GNT1155075). This work was also supported by the Victorian Operational Infrastructure Support Program.