Journal article

Pattern and degree of individual brain atrophy predicts dementia onset in dominantly inherited Alzheimer's disease

Ophir Keret, Adam M Staffaroni, John M Ringman, Yann Cobigo, Sheng-Yang M Goh, Amy Wolf, Isabel Elaine Allen, Stephen Salloway, Jasmeer Chhatwal, Adam M Brickman, Dolly Reyes-Dumeyer, Randal J Bateman, Tammie LS Benzinger, John C Morris, Beau M Ances, Nelly Joseph-Mathurin, Richard J Perrin, Brian A Gordon, Johannes Levin, Jonathan Voeglein Show all



Introduction: Asymptomatic and mildly symptomatic dominantly inherited Alzheimer's disease mutation carriers (DIAD-MC) are ideal candidates for preventative treatment trials aimed at delaying or preventing dementia onset. Brain atrophy is an early feature of DIAD-MC and could help predict risk for dementia during trial enrollment. Methods: We created a dementia risk score by entering standardized gray-matter volumes from 231 DIAD-MC into a logistic regression to classify participants with and without dementia. The score's predictive utility was assessed using Cox models and receiver operating curves on a separate group of 65 DIAD-MC followed longitudinally. Results: Our risk score separated ..

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Awarded by National Institutes of Health

Awarded by Alzheimer's Association research fellowship

Awarded by Dominantly Inherited Alzheimer Network (DIAN) - National Institute on Aging (NIA)

Awarded by The National Institutes of Health

Funding Acknowledgements

This research was supported by the National Institutes of Health, grants P01 AG019724, -P30 AG062422, K24 AG045333, U19 AG063911, U01 AG045390, U54 NS092089, U01AG051218, P50AG016570, P50AG005142, K08AG022228, P30 AG066444; P01 AG03991; P01 AG026276; U19 AG032438, P30 AG010133, R01 AG019771, P30 AG010133, R01 AG019771, R01 AG057739, U01 AG024904, R01 LM013463, R01 AG068193, and U01 AG068057 and the Alzheimer's Association research fellowship to promote diversity grant AARFD-20-681815. Data collection and sharing for this project was supported by The Dominantly Inherited Alzheimer Network (DIAN, UF1AG032438) funded by the National Institute on Aging (NIA), the German Center for Neurodegenerative Diseases (DZNE), Raul Carrea Institute for Neurological Research (FLENI), with partial support by the Research and Development Grants for Dementia from Japan Agency for Medical Research and Development, AMED, and the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI). This manuscript has been reviewed by DIAN Study investigators for scientific content and consistency of data interpretation with previous DIAN Study publications. We acknowledge the altruism of the participants and their families and contributions of the DIAN research and support staff at each of the participating sites for their contributions to this study.