Journal article

EPIGENETIC CHANGES ENCOMPASSING THE IGF2/H19 LOCUS ASSOCIATED WITH RELAXATION OF IGF2 IMPRINTING AND SILENCING OF H19 IN WILMS-TUMOR

T TANIGUCHI, MJ SULLIVAN, O OGAWA, AE REEVE

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | NATL ACAD SCIENCES | Published : 1995

Abstract

In most tissues IGF2 is expressed from the paternal allele while H19 is expressed from the maternal allele. We have previously shown that in some Wilms tumors the maternal IGF2 imprint is relaxed such that the gene is expressed biallelically. We have now investigated this subset of tumors further and found that biallelic expression of IGF2 was associated with undetectable or very low levels of H19 expression. The relaxation of IGF2 imprinting in Wilms tumors also involved a concomitant reversal in the patterns of DNA methylation of the maternally inherited IGF2 and H19 alleles. Furthermore, the only specific methylation changes that occurred in tumors with relaxation of IGF2 imprinting were ..

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