Journal article

ALTERED SPECIFICITY OF IGF2 PROMOTER IMPRINTING DURING FETAL DEVELOPMENT AND ONSET OF WILMS-TUMOR

T TANIGUCHI, AE SCHOFIELD, JL SCARLETT, IM MORISON, MJ SULLIVAN, AE REEVE

ONCOGENE | STOCKTON PRESS | Published : 1995

Abstract

The specificity of IGF2 promoter imprinting was examined in embryonal tissues and Wilms tumour. In several fetal tissues of approximately 12 weeks gestation, IGF2 was found to be monoallelically expressed from all IGF2 promoters i.e. P1, P2, P3 and P4. However, in tissues of slightly older gestation age (15-17 weeks) relaxation of imprinting at the P1 promoter was evident, although the P2-P4 promoters remained imprinted. These data indicate that early in embryogenesis a population of cells exists in which all IGF2 promoters are imprinted, but that as development proceeds the imprinting of the P1 promoter is relaxed. The pattern of IGF2 promoter imprinting was also analysed in Wilms tumour. I..

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