Effects of immunosuppression on the efficacy of vaccination against Mycoplasma gallisepticum infection in chickens
Sathya N Kulappu Arachchige, Anna Kanci Condello, Ling Zhu, Pollob K Shil, Kelly A Tivendale, Gregory J Underwood, Amir H Noormohammadi, Glenn F Browning, Nadeeka K Wawegama
VETERINARY MICROBIOLOGY | ELSEVIER | Published : 2021
Immunosuppression can increase the susceptibility of chickens to other disease-causing pathogens and interfere with the efficacy of vaccination against those pathogens. Chicken anaemia virus (CAV) and infectious bursal disease virus (IBDV) are common causes of immunosuppression in chickens. Immunosuppression was induced by experimental infection with either CAV or IBDV to assess the effect of immunosuppression on the efficacy of vaccination with Mycoplasma gallisepticum strain ts-304 against infection with virulent M. gallisepticum, a common bacterial pathogen of chickens worldwide. Birds were experimentally infected with either CAV or IBDV at 1 week of age, before vaccination and challenge ..View full abstract
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Awarded by Bio-properties Pty. Ltd. through ARC
This study was funded by the Australian Research Council and Bio-properties Pty. Ltd. through ARC Linkage Project grant LP160101105. Sathya N. Kulappu Arachchige was supported by Melbourne International Fee Remission and Melbourne Research Scholarships. The authors gratefully acknowledge the assistance of Ms. June Daly and Ms. Angela Chircop for care of the birds, and Ms. Faye Docherty and Mr. Paul Benham for their assistance in tissue processing and staining.