Journal article

Potential gut-brain mechanisms behind adverse mental health outcomes of bariatric surgery

Robyn M Brown, Eva Guerrero-Hreins, Wendy A Brown, Carel W le Roux, Priya Sumithran

NATURE REVIEWS ENDOCRINOLOGY | NATURE PORTFOLIO | Published : 2021

Abstract

Bariatric surgery induces sustained weight loss and metabolic benefits via notable effects on the gut-brain axis that lead to alterations in the neuroendocrine regulation of appetite and glycaemia. However, in a subset of patients, bariatric surgery is associated with adverse effects on mental health, including increased risk of suicide or self-harm as well as the emergence of depression and substance use disorders. The contributing factors behind these adverse effects are not well understood. Accumulating evidence indicates that there are important links between gut-derived hormones, microbial and bile acid profiles, and disorders of mood and substance use, which warrant further exploration..

View full abstract

Grants

Awarded by ARC DECRA Fellowship


Awarded by National Health and Medical Research Council Investigator Grant


Funding Acknowledgements

This manuscript received no external funding. R.M.B. acknowledges the support of an ARC DECRA Fellowship (DE190101244). P.S. acknowledges the support of a National Health and Medical Research Council Investigator Grant (1178482). We acknowledge the numerous researchers whose work we were unable to cite due to space limitations.