Designing effective Wolbachia release programs for mosquito and arbovirus control

Abstract

Mosquitoes carrying endosymbiotic bacteria called Wolbachia are being released in mosquito and arbovirus control programs around the world through two main approaches: population suppression and population replacement. Open field releases of Wolbachia-infected male mosquitoes have achieved over 95% population suppression by reducing the fertility of wild mosquito populations. The replacement of populations with Wolbachia-infected females is self-sustaining and can greatly reduce local dengue transmission by reducing the vector competence of mosquito populations. Despite many successful interventions, significant questions and challenges lie ahead. Wolbachia, viruses and their mosquito hosts ..