Journal article

Chemotherapy-Induced Myopathy: The Dark Side of the Cachexia Sphere

Dean G Campelj, Craig A Goodman, Emma Rybalka

CANCERS | MDPI | Published : 2021

Abstract

Cancer cachexia is a debilitating multi-factorial wasting syndrome characterised by severe skeletal muscle wasting and dysfunction (i.e., myopathy). In the oncology setting, cachexia arises from synergistic insults from both cancer-host interactions and chemotherapy-related toxicity. The majority of studies have surrounded the cancer-host interaction side of cancer cachexia, often overlooking the capability of chemotherapy to induce cachectic myopathy. Accumulating evidence in experimental models of cachexia suggests that some chemotherapeutic agents rapidly induce cachectic myopathy, although the underlying mechanisms responsible vary between agents. Importantly, we highlight the capacity o..

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Grants

Awarded by Institute for Sport, Exercise, and Active Living


Funding Acknowledgements

This research was funded by a program establishment grant (62962602) from the Institute for Sport, Exercise, and Active Living and the Centre for Chronic Disease, Victoria University (now the Institute for Health and Sport, Victoria University).