Journal article

White Matter Alterations Between Brain Network Hubs Underlie Processing Speed Impairment in Patients With Schizophrenia

Paul Klauser, Vanessa L Cropley, Philipp S Baumann, Jinglei Lv, Pascal Steullet, Daniella Dwir, Yasser Alemán-Gómez, Meritxell Bach Cuadra, Michel Cuenod, Kim Q Do, Philippe Conus, Christos Pantelis, Alex Fornito, Tamsyn E Van Rheenen, Andrew Zalesky

Schizophrenia Bulletin Open | Oxford University Press (OUP) | Published : 2021

Abstract

Abstract Processing speed (PS) impairment is one of the most severe and common cognitive deficits in schizophrenia. Previous studies have reported correlations between PS and white matter diffusion properties, including fractional anisotropy (FA), in several fiber bundles in schizophrenia, suggesting that white matter alterations could underpin decreased PS. In schizophrenia, white matter alterations are most prevalent within inter-hub connections of the rich club. However, the spatial and topological characteristics of this association between PS and FA have not been investigated in patients. In this context, we tested whether structural connections comprising the rich club n..

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